A NOVEL PD-L1-TARGETED SHARK VNAR SINGLE-DOMAIN-BASED CAR-T CELL STRATEGY FOR TREATING BREAST CANCER AND LIVER CANCER

A novel PD-L1-targeted shark VNAR single-domain-based CAR-T cell strategy for treating breast cancer and liver cancer

Chimeric antigen receptor (CAR)-T cell therapy shows excellent potency against hematological malignancies, but it remains challenging to treat solid tumors, mainly because of a lack of appropriate antigenic targets and an immunosuppressive tumor microenvironment (TME).The checkpoint molecule programmed death-ligand 1 (PD-L1) is widely overexpressed

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Small crickets of New Zealand (Orthoptera: Grylloidea: Trigonidiidae and Mogoplistidae), with the description of two new genera and species

Crickets (Order Orthoptera, Infraorder Gryllidea) are under-represented in New Zealand, with a total of eight species identified and formally described thus far.These include three endemic species in the family Trigonidiidae: the trig Trigonidium (Metioche) maoricum (Walker, 1869) and the ground crickets Bobilla nigrova (Swan, 1972) and B.bigelowi

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Methodology and device for diagnostics of high-voltage insulators based on continuous recording of the spatial level of electromagnetic radiation of partial discharges

THE PURPOSE.Development of diagnostic methods for high-voltage insulators in operation based on continuous recording of electromagnetic radiation.Hardware and software implementation of the device based on this technique.Carrying out kaimana youth services experimental researches.METHODS.Received signal strength indicator measuring method of electr

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Analyzing Land Use and Land Cover Dynamics Using Geospatial Approaches: A Case Study of District Lahore, Pakistan

The present study focuses on the city of Lahore due to the substantial impacts of LULC on land-atmosphere climatic interactions.This study aims to find and interpret the variations in land use patterns in Lahore during 20 years (2003, 2013, and 2023) with a ten-year interval.For in-depth analysis, four different classes- built-up, barren land, vege

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